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タイトル: Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats
著者: Han, Chong
Inaba, Wataru
Yonekura, Manabu
Ogata, Yoshiki
Ohba, Takayoshi
Kushikata, Tetsuya
Niwa, Hidetoshi
Yanagisawa, Teruyuki
Tomita, Hirofumi
Itagaki, Shirou
Hirota, Kazuyoshi
Akai, Hiroaki
Mizukami, Hiroki
Murakami, Manabu
著者所属: Department of Pharmacology
Department of Pathology and Molecular Medicine
Department of Cardiology
Department of Pharmacology
Department of Cellphysiology, Akita University School of Medicine, Akita
Department of Anesthesiology
Department of Anesthesiology
Department of MolecularPharmacology, Tohoku University School of Medicine
Department of Cardiology
Department of Pharmacy, Hirosaki University, Graduate School of Medicine
Department of Anesthesiology
Department of Metabolism and Diabetes, Tohoku Medical Pharmaceutical University
Department of Pathology and Molecular Medicine
Department of Pharmacology
発行日: 5-Oct-2017
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 68
号: 1
開始ページ: 33
終了ページ: 43
ISSN: 0439-1721
キーワード: rats
parasympathetic nerve
diabetes mellitus
抄録:  Persistent hyperglycemia is implicated in the pathogenesis of chronic diabetic complications, such as neuropathy. Therefore, we investigated Electrocardiogram( ECG)-related changes, including various ECG parameters and heart rate variability, and neuropathic changes in diabetic Goto-Kakizaki (GK) rats, a spontaneous model for type 2 diabetes. GK rats (50 weeks old) showed increased plasma glucose and decreased R-R interval variability, which was likely due to diabetic polyneuropathy in the autonomic nervous system. Interestingly, GK rats showed a decreased baroreflex compared with control Wistar rats. Furthermore, GK rats showed limited fluctuation changes in beat-to-beat dynamics. In the frequency domain analysis, the low-frequency component was similar but the highfrequency component was significantly decreased in GK rats, suggesting decreased parasympathetic nerve regulation and conserved sympathetic nerve regulation. In addition, GK rats showed a limited response to high-dose atropine, a muscarinic receptor antagonist, indicating modified parasympathetic nerve regulation in GK rats. Our data strongly suggests that GK rat could be a nice animal model for chronic cardiovascular disease related to diabetic neuropathy.
URI: http://hdl.handle.net/10129/6146
テキストバージョン: publisher

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