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30b 弘前医学 = Hirosaki Medical Journal >
67巻2-4号 >

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タイトル: Effects of Enflurane on Cardiac Autonomic Nervous Activity in Mice
著者: Ogata, Yoshiki
Yonekura, Manabu
Yamaki, Rouichi
Han, Chong
Fujiwara, Tomonori
Seya, Kazuhiko
Niwa, Hidetoshi
Kushikata, Tetsuya
Imaizumi, Tadaatsu
Hirota, Kazuyoshi
Tomita, Hirofumi
Murakami, Manabu
著者所属: Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
発行日: 27-Feb-2017
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 2-4
開始ページ: 153
終了ページ: 157
ISSN: 0439-1721
キーワード: Autonomic nervous system
enflurane
halothane
inhalation anesthesia
mice
抄録: We examined the effects of enflurane anesthesia on the mouse cardiac autonomic nervous system using electrocardiogram( ECG) analysis. Enflurane had a lower effect on heart rate( HR) compared to isoflurane, which is more widely used in small animal studies. Under anesthesia with 3 or 4% of enflurane, administration of propranolol had a significant effect on HR. Enflurane increased R-R interval length in a dose-dependent fashion, and the R-R interval became unstable at high concentrations. Although HR decreased with high doses of enflurane, we observed normal sinus rhythm and no arrhythmia. These results suggest that the effect of enflurane anesthesia is acceptable even though the drug can lead to cardiac instability. No remarkable changes were observed in HR frequency. These results suggest that enflurane anesthesia may be suitable for cardiac autonomic nervous system analysis.
URI: http://hdl.handle.net/10129/6015
テキストバージョン: publisher
出現コレクション:67巻2-4号

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