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67巻2-4号 >

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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10129/6012

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タイトル: Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice
著者: Nozaki, Shuhei
Ogata, Yoshiki
Yonekura, Manabu
Han, Chong
Niwa, Hidetoshi
Kushikata, Tetsuya
Hirota, Kazuyoshi
Matsuzaki, Yasushi
Tomita, Hirofumi
Imaizumi, Tadaatsu
Itagaki, Shirou
Sawamura, Daisuke
Murakami, Manabu
著者所属: Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki UniversityGraduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Anesthesiology, Hirosaki University Graduate School of Medicine
Department of Dermatology, Hirosaki University Graduate School of Medicine
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
Department of Pharmacy, Hirosaki University, Graduate School of Medicine
Department of Dermatology, Hirosaki University Graduate School of Medicine
Department of Pharmacology, Hirosaki UniversityGraduate School of Medicine
発行日: 27-Feb-2017
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 2-4
開始ページ: 129
終了ページ: 135
ISSN: 0439-1721
キーワード: Inhalation halothane anesthesia
barbiturate; mouse
mouse
ECG
抄録: We analyzed the effects of halothane as an inhalational anesthetic agent on electrocardiogram (ECG) parameters in C57/BL6 mice. Following induction of anesthesia using 2% halothane, the ECGs showed a regular pattern and the heart rate (HR) was within an acceptable range (~500 bpm). The HR decreased with increasing halothane concentration in a concentration-dependent fashion.   The frequency domain analysis showed that the high-frequency (HF) component decreased and the lowfrequency (LF) component increased in a concentration-dependent fashion. Therefore, the LF/HF ratio increased with increasing halothane concentration, suggesting effects on the autonomic nervous system.   We analyzed the pharmacological response to sympathetic blockade with propranolol, a typical adrenergic β-blocker, under halothane anesthesia. Propranolol administration resulted in a decreased HR; interestingly, intraperitoneal injection of propranolol (120 μg/kg body weight) resulted in arrhythmia (sick sinus syndrome) during anesthesia with 3% halothane.  Our results indicate the importance of selecting a suitable anesthetic agent for C57/BL6 mice in pharmacological studies
URI: http://hdl.handle.net/10129/6012
テキストバージョン: publisher
出現コレクション:67巻2-4号

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