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タイトル: Morphological Analysis of the Residual Rectal Mucosa in 12 Postoperative Ulcerative Colitis Patients
著者: Morohashi, Satoko
Morohashi, Hajime
Yoshizawa, Tadashi
Tanaka, Masanori
Mikami, Tatsuya
Kagiya, Takuji
Saito, Takeshi
Hirai, Hideaki
Haga, Toshihiro
Wu, Yunyan
Hakamada, Kenichi
Kijima, Hiroshi
著者所属: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Department of Gastroenterological Surgery, HirosakiUniversity Graduate School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Department of Pathology, Hirosaki Municipal Hospital
Department of Gastroenterology and Hematology,Hirosaki University Graduate School of Medicine
Department of Gastroenterological Surgery, HirosakiUniversity Graduate School of Medicine
Department of Gastroenterological Surgery, HirosakiUniversity Graduate School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Department of Gastroenterological Surgery, HirosakiUniversity Graduate School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
発行日: 29-Jul-2016
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 1
開始ページ: 92
終了ページ: 101
ISSN: 0439-1721
キーワード: rectum
ulcerative colitis
residual rectal mucosa
抄録: There are no reports on the degree of inflammation in the residual rectal mucosa in asymptomatic UC patients after an operation for ileal pouch anal canal anastomosis( IACA). Methods: We studied the residual rectal mucosal biopsies and rectal mucosa from the surgical specimens of 12 asymptomatic postoperative UC cases. We analyzed the degree of inflammation, including crypt architecture and mucus content in the rectal mucosa. Results: Two pathological active cases (16.7%), four resolving cases (33.3%), and six remission cases (50%) were observed in the residual rectal mucosa. In terms of the degree of pathological inflammation in the residual rectal mucosa, one case (1/12, 8.3%) was upregulated, seven cases (7/12, 58.3%) were stable, and four cases (4/12, 33.3%) were downregulated compared with the rectal mucosa of the surgical specimens. Conclusions: We determined the natural history of the degree of inflammation on the residual rectal mucosa in postoperative UC patients. Eight cases (8/12, 66.6%) of asymptomatic UC patients were associated with prolonged inflammation after an IACA operation in the residual rectal mucosa compared with that in the rectal mucosa of the surgical specimens. Therefore, we could identify patients with prolonged inflammation in asymptomatic UC cases by a residual rectal mucosal biopsy.
URI: http://hdl.handle.net/10129/5925
テキストバージョン: publisher
出現コレクション:67巻1号

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