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このアイテムは、前月 15 件の閲覧がありました。

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10129/5923

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タイトル: The Cardiorespiratory Responses to Inhalation and Pentobarbital Anesthesia in the Mouse
著者: Chong, Han
Ogata, Yoshiki
Niwa, Hidetoshi
Kushikata, Testuya
Watanabe, Hiroyuki
Imaizumi, Tadaatsu
Hirota, Kazuyoshi
Ono, Kyouichi
Ohba, Takayoshi
Murakami, Manabu
著者所属: Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine
Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine
Department of Anesthesiology, Hirosaki University Graduates School of Medicine
Department of Anesthesiology, Hirosaki University Graduates School of Medicine
Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine
Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduates School of Medicine
Department of Anesthesiology, Hirosaki University Graduates School of Medicine
Department of Cellphysiology, Akita University School of Medicine
Department of Cellphysiology, Akita University School of Medicine
Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine
発行日: 29-Jul-2016
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 1
開始ページ: 77
終了ページ: 85
ISSN: 0439-1721
キーワード: Inhalation isoflurane anesthesia
pentobarbital
hemodynamic status
blood gas
抄録: Transgenic mice experiments have become increasingly popular to research human inherited disease. However, a number of Japanese researchers have difficulty with the selection of anesthesia, after the classification of ketamine, probably the most used anesthesia, as a narcotic drug in 2006. Therefore, we compared the effects of inhalation anesthesia (2% of isoflurane, sevoflurane and enflurane) and intraperitoneal pentobarbital anesthesia (50 mg/kg) on the electrocardiogram( ECG) and blood oxygen saturation( SPO2) of mice. With inhalation anesthesia, the heart rate( HR) and SPO2 were within an acceptable range. In contrast, the HR significantly decreased after initiation of pentobarbital anesthesia, and gradually returned to a low rate. Importantly, pentobarbital anesthesia significantly lowered SPO2, and heart rate variability analysis showed unstable beat-to-beat intervals during pentobarbital anesthesia, suggesting that inhalation anesthesia is more suitable for evaluation of cardiorespiratory responses than pentobarbital anesthesia. During anesthesia, propranolol, a 􀈕-adrenergic blocker, significantly decreased heart rate. Atropine, a parasympathetic blocker, also significantly increased heart rate. Our data suggest that inhalation  anesthesia is suitable for cardiorespiratory analysis in mice.
URI: http://hdl.handle.net/10129/5923
テキストバージョン: publisher
出現コレクション:67巻1号

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