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67巻1号 >

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タイトル: Phenotypic Characterization of Early Biliary Tract Carcinomas Proposes Two Carcinogenesis Pathways
著者: Haga, Toshihiro
Yoshizawa, Tadashi
Morohashi, Satoko
Hirai, Hideaki
Saitou, Kensuke
Ota, Rie
Takatsuna, Masafumi
Wu, Yuyan
Fukuda, Shinsaku
Kijima, Hiroshi
著者所属: Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Medical Oncology, Hirosaki University Graduates School of Medicine
Department of Gastroenterology, Hirosaki UniversityGraduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
Department of Gastroenterology, Hirosaki UniversityGraduates School of Medicine
Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine
発行日: 29-Jul-2016
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 1
開始ページ: 28
終了ページ: 38
ISSN: 0439-1721
キーワード: Early biliary tract carcinoma
carcinogenesis
metaplasia
immunohistochemistry
抄録: Early biliary tract carcinomas( BTCs) are divided into three groups: early gallbladder carcinoma( GBC), early extrahepatic bile duct carcinoma (EBC), and early duodenal ampullary carcinoma (DAC). These early carcinomas frequently show metaplastic changes. However, phenotypic characterization has not yet been examined. We examined 76 lesions of surgically resected early biliary tract carcinomas (pTis/pT1 tumors according to TNM classification). The predominant carcinoma phenotypes were classified with hematoxylin and eosin (HE) stain, and immunohistochemical examinations (MUC1, MUC2, MUC5AC, MUC6, and CD10) were performed. We also analyzed phenotypes of the surrounding non-neoplastic mucosa. Of the 33 early GBCs, 18 (54.5%) were biliary type, and 15 (45.5%) were metaplastic type (gastric foveolar type/intestinal type) carcinoma. Of the 26 early EBCs, 18 (69.2%) were biliary type carcinoma, and eight( 30.8%) were metaplastic type carcinoma. Of the 17 early DACs, eight( 47.1%) were biliary type carcinoma, nine (52.9%) were metaplastic type carcinoma. Biliary type carcinomas less frequently showed metaplastic changes, while metaplastic type carcinomas were frequently surrounded by the metaplastic mucosa. Early GBC and early DAC more frequently showed metaplastic changes, compared to the early EBC. In conclusion, we speculated that two carcinogenesis pathways of early BTC (GBC, EBC, and DAC): (1) carcinomas arising from the proper epithelium (mainly EBC) and (2) carcinomas from the metaplastic epithelium (mainly GBC and DAC).
URI: http://hdl.handle.net/10129/5918
テキストバージョン: publisher
出現コレクション:67巻1号

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