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30b 弘前医学 = Hirosaki Medical Journal >
67巻1号 >

このアイテムは、前月 4 件の閲覧がありました。

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10129/5917

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タイトル: Association of Sex Steroid Hormones wth Neutrophil Function in the General Population
著者: Sato, Satoshi
Komame, Hitomi
Akimoto, Naoki
Sawada, Kaori
Tanaka, Rina
Munakata, Osamu
Iizuka, Hiroshi
Shibata, Nobuyuki
Nakaji, Shigeyuki
著者所属: Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Cancer Epidemiology and Community Health, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
Department of Social Medicine, Hirosaki University Graduate School of Medicine
発行日: 29-Jul-2016
出版者: 弘前大学大学院医学研究科・弘前医学会
誌名: 弘前医学
巻: 67
号: 1
開始ページ: 13
終了ページ: 27
ISSN: 0439-1721
キーワード: sex steroid hormones
neutrophil
reactive oxygen species
oxidative stress
general population
抄録: There are certain sex differences in the prevalence and severity of immunity-related diseases. Previous studies have shown the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system. The aim of this study was to investigate the association of sex steroid hormones with neutrophil function among normal healthy subjects in the general population. Subjects included 540 residents( 358 males and 182 females), who participated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosterone with neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlated with basal ROS production in males and luteal phase females (>15th day of menstrual cycle), although such trend was not observed in follicular phase females( <14th day of menstrual cycle) and postmenopausal females. In contrast, the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males. In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore, the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.
URI: http://hdl.handle.net/10129/5917
テキストバージョン: publisher
出現コレクション:67巻1号

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