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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10129/5109


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タイトル: Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit
著者: Naraoka, Masato
Munakata, Akira
Matsuda, Naoya
Shimamura, Norihito
Ohkuma, Hiroki
著者所属: 弘前大学大学院医学研究科
Department of Neurosurgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8216, Japan
発行日: Jan-2013
出版者: Springer
誌名: Translational Stroke Research
巻: 4
号: 3
開始ページ: 368
終了ページ: 374
ISSN: 1868-4483
DOI: 10.1007/s12975-012-0247-9
キーワード: Cerebral vasospasm
Rho/Rho-kinase pathway
抄録: The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS.
内容記述: Open Access Article
URI: http://hdl.handle.net/10129/5109
テキストバージョン: ETD
学位授与番号: 11101A1807
学位授与年月日: 2013-09-30
学位名: 博士(医学)
学位授与機関: 弘前大学

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